Inflammatory neuropathies represent disabling human autoimmune disorders with considerable disease variability.Animal models provide insights into defined aspects of their disease pathogenesis.Forkhead box P3 (FoxP3)+ regulatory T lymphocytes (Treg) are anti-inflammatory cells that maintain immune tolerance and counteract tissue damage in a variety

Electroencephalographic (EEG) source reconstruction is a powerful approach that allows anatomical localization of electrophysiological brain activity.Algorithms used to estimate cortical sources require an anatomical model of the head and the brain, generally reconstructed using magnetic resonance imaging (MRI).When such scans are unavailable, a po

Abstract Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 antibodies have been extensively explored over the recent years to unleash otherwise compromised anti-cancer immune responses.However, it is also well established that immu

The present study was carried on assess the lifespan extension of Caenorhabditis elegans (C.elegans) by astaxanthin (AST) and its related molecular mechanisms.The effect of AST on the lifespan of wild-type (WT) nematodes was observed, the relative expression of antioxidant (sod-3, ctl-1) and autophagy-related genes (bec-1, lgg-1) in WT Floater Pole

Seven years after the seminal paper on FAIR was published, that introduced the concept of making research outputs Findable, Accessible, Interoperable, and Reusable, researchers still struggle to understand how to implement the principles.For many researchers, FAIR promises long-term benefits for near-term effort, requires skills not yet acquired, a